{"product_id":"improving-and-accelerating-therapeutic-development-for-nervous-system-disorders","title":"Improving and Accelerating Therapeutic Development for Nervous System Disorders","description":"\u003ch1\u003e\u003cspan style=\"color: #262626;\"\u003eImproving and Accelerating Therapeutic Development for Nervous System Disorders\u003c\/span\u003e\u003c\/h1\u003e\n\u003cp\u003e\u003cspan style=\"color: #262626;\"\u003eImproving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disordersidentifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #262626;\"\u003e\u003cbr\u003e\u003cstrong\u003eAutor:\u003c\/strong\u003e\u003cbr\u003e AA. VV.\u003cspan style=\"color: #b3b3b3;\"\u003e\u003cem\u003e)\u003c\/em\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #262626;\"\u003e\u003cstrong\u003eCaracterísticas técnicas:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"color: #262626;\"\u003eTamaño cerrado 152 x 238 mm\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"color: #262626;\"\u003e118 páginas interiores\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"color: #262626;\"\u003eTapa rústica\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"color: #262626;\"\u003eEncuadernación lomo cuadrado\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #262626;\"\u003e\u003cspan style=\"color: #262626;\"\u003eEn Webook cuidamos el medio ambiente, imprimimos lo justo y este libro lo haremos especialmente para ti \u003cmeta charset=\"utf-8\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Bibliomanager","offers":[{"title":"Default Title","offer_id":46779059339401,"sku":"001-0000293677","price":47100.0,"currency_code":"CLP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0688\/5703\/6937\/files\/1501830_IMAGEN_TAPA_G_002.jpg?v=1779318201","url":"https:\/\/webook.cl\/products\/improving-and-accelerating-therapeutic-development-for-nervous-system-disorders","provider":"WeBook","version":"1.0","type":"link"}